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Toujeo Max Solostar: 7 things you should know

Toujeo Max Solostar: 7 things you should know

Medically reviewed by Carmen Fookes, BPharm. Last updated on Jul 31, 2020.

1. How it works
  • Toujeo Max Solostar is a brand name for a type of long-acting insulin prefilled pen that contains insulin glargine at a concentration of 300 units/mL.
  • Insulin glargine is a biosynthetic human insulin analog of rDNA origin that has been made using genetic engineering technology. Although it resembles human insulin in most of its structure, the amino acid arginine in position A21 has been replaced by glycine and two arginines have been added to the C-terminus of the B-chain.
  • Toujeo Max Solostar was formulated to be convenient to use and have a low insulin solubility at neutral pH which means it forms microprecipitates when injected under the skin (subcutaneously), which allows the insulin to be released slowly from the injection site. Toujeo Max Solostar is the same concentration as Toujeo Solostar but more concentrated than other insulin glargine, such as Lantus Solostar.
  • The primary activity of insulin, which includes Toujeo Max Solostar, is to allow cells throughout the body to uptake glucose (sugar) and convert it into a form that can be used by these cells for energy.
2. Upsides
  • May be used for the treatment of type 1 diabetes in adults and children over the age of six who require a long-acting insulin for their diabetes control.
  • Toujeo Max Solostar is a long-acting insulin that lasts up to 36 hours. Only needs to be given once a day; however, twice-daily administration may lessen the risk of hypoglycemia.
  • May be used to control blood sugar levels in adults with type 2 diabetes who require a long-acting insulin when other medications are no longer effective at improving blood sugar levels.
  • Toujeo Max Solostar is a prefilled pen that is for single patient-use. This 3mL pen contains 900 units of insulin (at a concentration of 300U/mL). Units can be increased by 2 units at a time by moving the dial on the pen. The maximum dosage that can be given with one injection is 160 units.
  • Concentrated forms of insulin have been shown to last longer in the body with less variability in blood levels over time. This translates to a lower risk of hypoglycemia, especially at night.
  • Toujeo Max Solostar does not pass into breast milk and will not affect a nursing infant.
3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Low blood sugar levels (hypoglycemia) are the most common side effect of Toujeo Max Solostar. The risk of hypoglycemia increases with tighter blood sugar controls, changes in meal patterns, with certain coadministered medications, and changes in physical activity levels. People with liver or kidney disease may be at a higher risk of hypoglycemia.
  • All insulins can cause potassium levels to go low (this is called hypokalemia). Insulin may also cause sodium retention, weight gain, fluid retention and swelling, itching, redness, or lumps around the injection site. There is a risk of infection if a Toujeo Max Solostar pen is shared.
  • The dosage of Toujeo Max Solostar may need to be reduced in liver or kidney disease. Blood glucose levels should be carefully monitored in people with these conditions.
  • Seniors may be more susceptible to the side effects of long-acting insulins, such as insulin glargine. The dosage of Toujeo Max Solostar in elderly people should be conservative.
  • Toujeo Max Solostar must be given by subcutaneous (under the skin) injection. It should not be given by IV, IM, or via an infusion pump.
  • Toujeo Max Solostar is not suitable for the treatment of diabetic ketoacidosis. Short-acting insulins should be used to treat this condition.
  • Seniors may have more difficulty using the Toujeo Max Solostar pen due to poor vision or dexterity problems, making it difficult to dial the correct dosage or inject the insulin under their skin.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here. 4. Bottom Line

  • Toujeo Max Solostar contains insulin glargine in a prefilled pen at a higher concentration than other forms of insulin glargine, such as Lantus Solostar. Toujeo Max Solostar contains 900 units of insulin in total, compared to only 450 units with Toujeo Solostar. Toujeo Max Solostar is recommended for people requiring higher dosages of insulin, because up to 160 units may be administered at any one time.
5. Tips
  • Tell your doctor if you have ever had an allergic reaction to any type of insulin before you start using Toujeo Max Solostar.
  • Children are especially sensitive to the effects of insulin, particularly around puberty.
  • There are so many different types of insulin that medication errors are common. Always check the label on your insulin to make sure it is the brand you have been prescribed and it is the correct strength. Talk to your doctor or pharmacist if you are unsure. Always make sure you dial up the correct dose of Toujeo Max Solostar for you.
  • The dosage of Toujeo Max Solostar needs to be individualized. This may take time, so ensure you monitor your blood sugars regularly when titrating the dosage of Toujeo Max Solostar, and tell your doctor the results.
  • Never share your Toujeo Max Solostar pen with other people. Store your pens as recommended on the label.
  • Inject your insulin exactly as directed by your doctor. Take all other medications as prescribed.
  • Your insulin requirements may change if you become unwell, develop an infection, or other medical conditions. Surgery, injury, mental stress, your diet, and how much exercise you do can also affect how much insulin you need. Puberty, pregnancy, and menopause can also affect insulin requirements. Conditions that delay food absorption or stomach emptying can slow down the time it takes to break down and absorb food which can change how much insulin you need.
  • Be alert for symptoms of hypoglycemia which may include a headache, sweating, trembling, anxiety, confusion, irritability, rapid breathing, or a fast heartbeat. People with hypoglycemia may also faint and severe hypoglycemia that is left untreated may be fatal. Tell your family, friends, and caregivers to give you some fast-acting sugar (such as some jellybeans, fruit juice, or honey) if they notice you have symptoms of hypoglycemia and then follow it up with a more substantial meal or glucagon injection if you are unconscious.
  • Insulin is easily broken down by extreme temperatures, which means you need to be careful if you live in a part of the U.S. that gets very hot in summer, or very cold in winter.
  • Toujeo Max Solostar that has been opened may be kept at room temperature (59 to 77 degrees Fahrenheit [15-25 degrees Celcius]) for up to 56 days, much longer than most other insulins that can only be left unrefrigerated for up to 28 days.
  • If you are going out in the sun, always use an insulated bag protected by a cool pack to ensure your Toujeo Max Solostar doesn't heat up; but avoid freezing it. During cold weather, keep your Toujeo Max Solostar close to your skin so your body heat keeps it at a more even temperature. Discard any Toujeo Max Solostar pens that you think may have inadvertently got too hot or too cold. The expiry date on Toujeo Max Solostar applies to unopened, refrigerated insulin.
6. Response and Effectiveness
  • Starts to work within 70 minutes after injection
  • Has no pronounced peak but full blood sugar-lowering effects can take 6 hours to develop after administration
  • Toujeo lasts for up to 36 hours and is usually given once a day, usually in the morning.
  • Even though Toujeo is usually given once a day, some people may experience better blood sugar control if the dose is split and given twice a day (every 12 hours). Those that tend to benefit from twice-daily Toujeo include those experiencing early morning hypoglycemia or persistent hyperglycemia at dinner time. Twice daily Toujeo can also improve HbA1c levels. Some reports have stated the risk of hypoglycemia may be up to 30% less with Toujeo compared to Lantus.
  • Toujeo Max Solostar is a higher volume pen than Toujeo Solostar. The Toujeo Max pen contains 900 units of insulin compared with 450 units for the Toujeo pen, although the concentration for both remains the same, 300 units/mL. This allows higher dosages to be given more easily.
7. Interactions

Medicines that interact with Toujeo Max Solostar may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Toujeo Max Solostar. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with Toujeo Max Solostar include:

  • antibiotics, such as doxycycline and minocycline
  • antidepressants such as SSRIs (eg, fluoxetine, sertraline), monoamine oxidase inhibitors (MAOI) such as selegiline, isocarboxazid, and phenelzine
  • antiepileptics, such as fosphenytoin and phenytoin
  • antipsychotics, such as aripiprazole, chlorpromazine
  • antivirals such as amprenavir, atazanavir, and fosamprenavir
  • aspirin
  • beta-blockers, such as acebutolol, atenolol, or timolol
  • cyclosporine
  • diuretics, such as furosemide, chlorthalidone, or hydrochlorothiazide
  • fluoroquinolone antibiotics, such as ciprofloxacin or norfloxacin
  • gemfibrozil
  • heart medications such as captopril, candesartan, or clonidine
  • hormones, such as estradiol, estrone, and norethindrone
  • lithium
  • niacin
  • pentamidine
  • salmeterol
  • steroids, such as cortisone, dexamethasone, fludrocortisone, or prednisone
  • sucralfate
  • tacrolimus or pimecrolimus
  • topiramate
  • turmeric
  • aloe vera
  • other insulins
  • other medications that affect blood sugar levels or are used for diabetes, such as chlorpropamide, glimepiride, or glipizide.

Alcohol may also interact with Toujeo Max Solostar by blocking the production of glucose by the liver, causing hypoglycemia.

Note that this list is not all-inclusive and includes only common medications that may interact with Toujeo Max Solostar. You should refer to the prescribing information for Toujeo Max Solostar for a complete list of interactions

References

Toujeo Max SoloStar (insulin glargine) [Package Insert] Sanofi-Aventis U.S. LLC https:// /cdi/toujeo-max-solostar.html

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Toujeo Max Solostar only for the indication prescribed.

Copyright 1996-2020 . Revision date: July 31, 2020.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Toujeo Max SoloStar (insulin glargine)
  • Side Effects
  • During Pregnancy
  • Dosage Information
  • Drug Interactions
  • Pricing & Coupons
  • Drug class: insulin
  • FDA Alerts (1)
Consumer resources
  • Toujeo Max SoloStar

Other brands: Lantus, Basaglar, Toujeo, Lantus SoloStar

Professional resources
  • Insulin Glargine (AHFS Monograph)
Related treatment guides
  • Diabetes, Type 1
  • Diabetes, Type 2

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